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Effect of Gancyclovir onProliferation and Differentiation of Chronic MyeloidLeukemia Cells and Research of ItsMechanism
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Abstract:
Objective: To explore whether gancyclovir (GCV) can inhibit the proliferation and induce the erythro differentiation of the K562 human myeloid leukemia cell line. Methods: K562 cells were cultured with GCV for 4 days to detect cellular changes cloning efficiency, benzidine positive rate, flow cytometry analysis, and telomerase activity. Results: When K562 cells grew in the medium containing GCV, the cellular growth and division were gradually suppressed, growth fracture decreased and further differentiation towards the cell producing hemoglobins was found. Conclusion: GCV can inhibit proliferation and induce erythro differentiation of K562 cells.
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