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Localization Effect of 131 I-Human Anti-HBs Fab in Nude Mice Models of Human Hepatoma
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Abstract:
Objective: To evaluate the targeting activity in the animal model with human hepatoma, the 131 I human anti HBsAg Fab radioimmunoimaging was explored. Methods: Radioimmunoimagings were taken on different intervals after injection of 131 I human anti HBsAg Fab to the nude mice and tissue distribution was measured. The human anti HBsAg Fab was compared with the murine monoclonal antibodies. Results: The experimental group developed tumor positive images after 3 days of radio labeled monoclonal antibodies injection, and the peak accumulation of radio activity on the 5th day. Statistics indicated the tumor/liver ratio of the human anti HBsAg Fab, murine monoclonal antibodies and the control groups were 5.4,4.0 and 0.9 respectively on the 7th day. Conclusions: Our results suggest that the 131 I human anti HBsAg Fab has a considerable targeting activity, and provide an evidence that it can be used as a novel humanized carrer for targeting therapy of hepatoma.
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