Mobile website
Apoptosis of K562 Cells Induced by 3,7-Dinitrodibenzobromonium Salt
- Article
- Figures
- Metrics
- Preview PDF
- Reference
- Related
- Cited by
- Materials
Abstract:
Objective: To investigate the antitumor activities and apoptosis mechanisms of 3,7-dinitrodibenzobromonium salt (cBr) on human chronic myelogenous leukemia K562 cell line in vitro. Methods: The antitumor activities of cBr were tested by Trypanblau exclusion test ,MTT coloretric assay and clonal forming test,and the mechanisms were studied by morphological analysis(microscopy,fluorescencemicroscopy,electron microscopy)and flow cytometry analysis.Results: cBr could inhibit of the proliferation K562 cells and kill them significantly.The effects varied with different time and doses,and IC 50 of cell colony forming rate was 0.497 mmol/L.Apoptosis rate tested by flow cytometry was 70.34%,and apoptotic characteristics could be found by microscopy and electron microscopy. Conclusions: cBr could inhibit K562 cell proliferation greatly,and could induce K562 cells into apoptosis.
Keywords:
Project Supported:
Clc Number:
