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Consecutive Immunizationwith Recombinant Fowlpox Virus and Nucleic AcidVaccine Plasmid
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Abstract:
Objective: To research influence of consecutive Immunization on cellular and humoral immunity in mice. Methods: We evaluated a consecutive immunization strategy priming with recombinant fowlpox virus vUTALG and boosting with nucleic acid vaccine plasmid pcDNAG encoding HIV-1 capsid protein Gag. Results: In immunized mice, the number of CD4 cells from splenic lymphocytes increased singnificantly and the proliferation response of splenocytes to Con A, LPS elevated markedly and HIV-1-specific antibody response could be induced. Conclusion: Consecutive immunization could increase cellular and humoral immunity response in mice.
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Clc Number:
R734.2
