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Archive > Volume 8 Issue 1 > 2001,8(1):52-54. DOI:10.3872/j.issn.1007-385X.2001.1.016 Prev Next

Construction andExpression of Recombinant Retroviral Vector Containing D-Amino Acid Oxidase cDNA

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    Abstract:
    Objective: To research influence of consecutive Immunization on cellular and humoral immunity in mice. Methods: We evaluated a consecutive immunization strategy priming with recombinant fowlpox virus vUTALG and boosting with nucleic acid vaccine plasmid pcDNAG encoding HIV-1 capsid protein Gag. Results: In immunized mice, the number of CD4 cells from splenic lymphocytes increased singnificantly and the proliferation response of splenocytes to Con A, LPS elevated markedly and HIV-1-specific antibody response could be induced. Conclusion: Consecutive immunization could increase cellular and humoral immunity response in mice.

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    Clc Number:
    R392 R394

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