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Treatment of the Colonal Cancer with Intratumoral Injection Combining 131 I- CL3 with 131 I-ch TNT
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Abstract:
To define the feasibility and superiority of radioimmunotherapy with l31 I labeled anti-nucleus antigen monoclonal antibody chTNT ( 131 I-chTNT) and l31 I labeled anti-cell membrane antigen CL 3 monoclonal antibody( 131 I-CL 3 )intratumora1 injection, provide experimental evidence for the application of radioimmunotheray with 131 I labeled kinds of monoclonal antibodies. Methods: Nude mice bearing subcutaneous human colonal cancer xenografts were treated by intratumoral injection of l31 I-CL 3 and/or with l31 I-chTNT. Alteration of the tumor size and measured the radioactivity concentration in tumor,liver,blood and kidney were observed.Results: The inhibitory rate(82.3%) in group treated with 131 I-CL 3 and 131 I-chTNT was higher than that of using l31 I-CL 3 (57.9%)or l31 I-chTNT(53 8%) alone.The same was the radioactivity concentration ratios(T/NT) of tumor to normal tissue in three groups. Conclusion: Intratumoral injection with 131 I labeled kinds of monoclonal antibodies can increase the concentration of l31 I labeled monoclonal antibodies in tumor and enhance the efficacy of the radioimmunotherapy.
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