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Suppression of Recombinant Secreted Human Prostate Secretory Protein of 94 Amino Acids(rsHPSP94) on Prostate Cancer Cell PC-3
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Abstract:
Objective: To investigate the effect of purified recombinant secreted human prostate secretory protein of 94 amino acids (rsHPSP94) on the growth of androgen-independent human prostate cancer cells (PC-3) and its potential mechanism of action. Methods:Cell growth inhibition rate was determined by MTT and cell cycle distribution was analysed by Flow cytometry(FCM) .Results: rsHPSP94, in a dose- and time-dependent manner, inhibited the growth of PC-3. Flow cytometric analysis showed that rsHPSP94 arrested the cell cycle in the G1-phase and induced the cell apoptosis after treatment for 48 h. Conclusion: These results suggest that rsHPSP94 can inhibit the growth of PC-3 by arresting the cell cycle in the G1-phase.
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