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The Immune Effects and Solid Tumor Growth of Arsenic Trioxide on Experimental H22 Hepatoma-Bearing Mice
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Abstract:
Objective： To explore the immune effects and the solid tumor growth of arsenic trioxide on experimental H22 Hepatoma-bearing mice.Methods：T lymphocyte subsets and NKcells activity were assessed by flow cytometry and improved MTT assay. Calculate the tumor inhibitory rates. Results: The percentage of CD3＋ cells and CD4＋ cells, the ratio of CD4+ cells to CD8+ cells, the activity of NK cells in the tumor control group were markedly lower (P<0.01) than those in the healthy control group. However, they were significantly higher in the tumor treatment than in the tumor control group. There was a higher percentage of CD4+ and NKCA in arsenic trioxide treatment group at high dosage than that at low dosage (P<0.05). The tumor inhibitory rates were 39.12% and 45.74% separately. A lot of inflammatory cells could be seen under optic microscopy. Conclusion：Arsenic trioxide can obviously increase the immune function of H22 Hepatoma-bearing mice and inhibit the growth of tumor body.
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