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The Reversion of Tumor Cells Malignant Phenotype Treated by ICA and PJM and Its Mechanism
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Abstract:
Objective: To explore the mechanism and reversion of malignant phenotypes in a highly metastatic human lung tumor cell line. Methods: Suppression of ICA and PJM on PG cell line and the effects of PJM and ICA on PG cells sensitivity to lysis by CD3AK effectors cell was studied by MTT assay; the expression of bcl-2 and c-fos was studied by RT-PCR and flow cytometry, the expression of HLA-A,B,C in PG cells was examined by flow cytometry. Results: ICA and PJM inhibited the growth of PG obviously. ICA and PJM could significantly enhance the expression of HLA-ABC antigen and c-fos gene. ICA and PJM decreased the expression of bcl-2 and enhanced the the susceptibility of PG cells to lysis by CD3AK cells.Conclusion: ICA and PJM can reverse the malignant phenotypes of PG cells, enhance the recognition and killing effect of T cells.
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