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Anti-Tumor Effects and Mechanism of the Product from Corynebacterium Parvum at Nano Scale (NCPP)
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Abstract:
Objective:To investigate the in vivo anti-tumor effect and its mechanism of NCPP. Methods:Ehrlich′s ascites carcinoma cells were injected into the peritoneal cavity of mice. On the day before the injection and then, every other day, NCPP and Corynebacterum Parvum( CPP ) were given in the same way, total 5 times. The survival rates of the tumor-carrying mice were analyzed. 10 days after the injection of NCPP and CPP, data were collected, including the phagocytic index and its rate of the macrophages, the level of the hydrogen peroxide and nitric oxide produced by the macrophages, splenic natural killing (NK) cell′s activity, and the proliferation of T cells. And splenic index was evaluated on the 14th day after the injection of NCPP and CPP. Results: Compared with the control group, the survival rates of tumor-bearing mice were significantly increased in both NCPP and CPP groups; NCPP and CPP groups induced higher levels of splenic index (>2 in everage); higher levels of macrophage activity (P<0.01), and splenic NK cell activity (P<005), However, there was no difference in all the parameters mentioned as above between NCPP group and CPP group. Conclusions: This study shows that NCPP plays the same role as CPP in the tumor inhibition and splenic stimulation,mainly through the activiting macrophage and NK cells.
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