Relation of the Amount of Circulating Endothelial Cells in Peripheral Blood and the Serum Level of VEGF in Tumor Patients

doi:10.3872/j.issn.1007-385X.2003.3.009

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Archive > Volume 10 Issue 3 > 2003,10(3):194-197. DOI:10.3872/j.issn.1007-385X.2003.3.009 Prev Next

Relation of the Amount of Circulating Endothelial Cells in Peripheral Blood and the Serum Level of VEGF in Tumor Patients

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Abstract:

Objective:To analyze the circulating endothelial cells (CECs) and circulating endothelial precursors (CEPs) in peripheral blood of tumor patients. Methods:CECs and CEPs were enumerated in 57 tumor patients and 15 healthy controls by 3-color flow cytometry. The serum level of angiogenesis related cytokines（VEGF, bFGF）was determined by ELISA method.Results：In tumor patients, mean value of CECs and CEPs was (0.378±0.047)% and (0059±0.013)% respectively. The serum level of VEGF and bFGF were (295.58±59.56) ng/L and (28.73±740) ng/L. The amount of CECs/CEPs positively correlated with the serum level of VEGF and bFGF. Conclusions: The CECs/CEPs and serum level of VEGF and bFGF of tumor patients was higher than those of normal controls. VEGF and bFGF may participate into the course of endothelial progenitors mobilization.

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