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Comparison of Tju103 and CTLA4-Ig in Induction of Tolerance in MHC Haploidentical Bone Marrow Transplantation in Mice
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Abstract:
Objective:To observe the respective effects of Tju103 and CTLA4-Ig on tolerance, post haploidentical mice bone marrow transplantation. Methods:In the presence of the recipient antigen, T cells from the haploidentical donors were first cultured with Tju103 or CTLA4-Ig, then mixed with the bone marrow cells and transfused into the recipients. At last, they were observed on the effect on tolerance post transplantation. Results: A. The only irradiated group: All the mice died of failure of hematopoiesis within 11 days post irradiation. B. The CTX-treated leukemia group: All the mice died of leukemia within 16-23 days. C.The only transplanted group: All cases died of GVHD within 21 days post transplantation. D. The CsA prophylaxis group: 5 mice died within 8-22 days after transplantation, of which one died of leukemia, and two died of GVHD and infection respectively leaving 5 survived over 30 days post transplantation. E. The Tju103 treated group: 4 mice died within 9-26 days post transplantation, of which one died of leukemia and infection respectively, and two died of GVHD leaving 6 mice survived over 30 days post transplantation. F. The CTLA4-Ig treated group: 2 mice died of GVHD within 17~26 days after transplantation leaving 8 survived over 30 days post transplantation. Conclusions:Tju103 or CTLA4-Ig could alone improve survival time and reduce incidence and degree of GVHD respectively. But CTLA4-Ig could preserve ability of GVL effect and anti-infection potential while Tju103 couldn′t.
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