Inhibition on Proliferation of Lung Cancer by Natural Product SPA

doi:10.3872/j.issn.1007-385X.2003.4.007

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Archive > Volume 10 Issue 4 > 2003,10(4):260-264. DOI:10.3872/j.issn.1007-385X.2003.4.007 Prev Next

Inhibition on Proliferation of Lung Cancer by Natural Product SPA

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Abstract:

Objective: To explore the inhibitory effect of algae sulfated polysaccharide（SPA） on the proliferation of lung cancer and its possible mechanism.Methods: Using in vitro cell culture and animal model to observe the effects of SPA given by oral administration on tumor proliferation,immune function and the ability of IL-1, IL-2 secretion.Results:SPA at dose of 20, 40, 80 mg/kg significantly inhibits tumor growth with inhibitory rates of 35.27%(P<0.01), 4829%(P<0.001), 65.41% respectively. Significant increase in phagocytic function, increase in serun hemolycin level, delayed allergic reaction and secrection of IL-1，IL-2 were observed after SPA administration. No direct inhibitory effect on proliferation of A459 adenocarcinoma cell was observed in vitro.Conclusion: SPA inhibits the growth of Lewis lung cancer possibly by modulating immune function.

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