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Expression of AKT and PTEN Protein and Their Relationship with Clinic Characteristics of Esophageal Carcinoma
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Abstract:
Objective:To investigate the expression of AKT and PTEN protein and their relationship with clinic characteristics of esophageal carcinoma.Methods: Expression of AKT and PTEN protein was examined by Western Blot and immunohistochemical method in the esophageal carcinoma and normal esophageal (control) tissue of 42 patients.Results: In tumor specimen, expression of AKT protein was increased as compared with control tissue(P<0.01), while PTEN protein was reduced compared with control tissue(P<0.01). A negative correlation was observed between AKT and PTEN(r=-0.583，P<0.01). Protein level of AKT was higher in Ⅲb-Ⅳ stage patients with low differentiatition and lymph node metastasis than those with Ⅱ-Ⅲastage, high defferentiatition and no lymph node metastasis(P<0.01). However, PTEN protein level was entirely contrary. Both of them were not related with age, sex and size of tumor(P>0.05).Conclusions: The hyperexpression of AKT may play an important role in the initiation and development of human esophageal carcinoma, while PTEN inhibit this process.
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