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Anti-Tumor Effect of Recombinant Human Endostatin on the Growth of Mouse Lewis Lung Carcinoma
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Abstract:
Objective:To investigate the anti-tumor effect of recombinant human Endostatin (rhu-Endostatin)on the growth of mouse Lewis lung carcinoma cells, and to elucidate the dose-effect relationship and its possible mechanism. Methods:Lewis lung carcinoma cells were inoculated to mice (10 6-/ml). When trmor size reached about 100 mm3, the mice were randomly divided into low, medium and high dose groups with saline and CSA \[100 mg/（kg·d)\] as control. Rhu-Endostatin \[5,15, 30 mg/(kg·d)\] was injected to mouse once a day for 21days. At the 22 nd day, mice were executed, the tumor weights was calculated, and sections of brain, lung, liver, spleen and kidney was subjected to physiological analysis. Results: Area under curve in the endostatin-treated group was obviously less than that in tamor control group (P<0.01). Pathological study revealed that lavge areal necrosis arose in tumor and newborn capillaries around the tumor disappeared. Conclusion: The results revealed that rhu-Endostatin inhibited the growth, metastasis and angiogenesis of mouse Lewis lung carcinoma with the highest inhibition rate of 58.8%.
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