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Effect of Granulocyte (-Macrophage) Colony-Stimulating Factor on Oral Mucositis Due to Concomitant Chemoradiotherapy in Locally Advanced Head and Neck Cancer Patients
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Abstract:
Objective: To evaluate the efficacy of granulocyte(-macrophage) colony stimulating factor［G(M)-CSF］ in the treatment of concomitant chemoradiotherapy-induced oral mucositis in locally advanced head and neck cancer patients.Metheds: Fifteen patients with locally advanced head and neck cancer was received concomitant chemoradiotherapy,while white blood cell count were less than 1.5×10 9/L with grade Ⅲ/Ⅳoral mucositis ,they were subcutaneously given G(M)-CSF at dose of 100-300 μg daily for 3-10 days.Results: After administration of G(M)-CSF,all of the patients had an augmantation of white blood cell count more than 5.0×10 9/L. Complete healing of oral mucositis occurred in 1 patient(CR), partial in 8 patients(PR),whereas 6 patients had no change and none was progressive,the objective response rate(CR+PR) was 60%.Conclusions: G(M)-CSF is proved effective for oral mucositis caused by concomitant chemoradiotherapy in locally advanced head and neck cancer patients.
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