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The Effects of Basil Polysaccharide on the Behavior of Tumor Metastasis
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Abstract:
Objective: To study the effect of basil polysaccharide (BP) on tumor cell metastasis and its mechanism through assays of intercellular communication and NK cytotoxicity.Methods: Metastasis of tumor cell ability was assayed by metrigel in vitro and the rate of pulmonary metastasis nodel was caluated. Using SLDT technique to test the effect of BP on recovering the function of cell Gap junction mediated intercellular communication (GJIC). NK cytotoxicity was measured by a standard 4 h 51 Cr-release assay. Results:Invasion and migration of tumor cells decreased significantly after treated with BP in vitro and in vivo.PG cells treated with BP for 8 h could recover the function of GJIC compared with the control. NK activity of mice bearing tumor treated with BP rose significantly. Conclusions: The resutls suggested that BP could inhibit tumor metastasis and might be a new candidate for antitumor metastasis agent.
Keywords:
basil polysaccharide, tumor metastases, GJIC, NK
Clc Number:
R730.54 Q784
