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Archive > Volume 11 Issue 2 > 2004,11(2):110-113. DOI:10.3872/j.issn.1007-385X.2004.2.008 Prev Next

Selective Removal of Alloreactive Cells from Haematopoietic Stem Cell Grafts

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    Abstract:
    Objective：To obtain alloantigen-specific hyporesponsivness via depletion of alloreactive cells from haematopoietic stem cell grafts.Methods：BALB/c mouse bone marrow-derived dendritic cells genetically engineered to express FasL were cultured with C57BL/6 mouse spleen lymphocytes, and MLR was performed to evaluate the alloantigen-specific hyporesponsivness.Results：FasL-transfected DC induced T cell apoptosis and inhibited alloantigen-specific hyporesponsiveness in vitro.Conclusion：DC transfected with FasL gene may prevent graft-versus-host disease by selective removal of alloreactive cells from haematopoietic stem cell grafts

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