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The Comparation on Th1/Th2 in Pleural Effusion with That in Peripheral Blood of Patients with Advanced Lung Cancer
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Abstract:
Objective：To investigate the effect of helper T cells (Th1 and Th2) and its important significance in judging prognosis of patients with advanced lung cancer. Methods： Interferon-γ (INF-γ) and interleukin-4 (IL-4) in plasma and pleural effusion were detected by enzyme-linked immunoassay in patients with advanced lung cancer, IFN-γ and IL-4 reflected activity of Th1 and Th2 respectively. Results： The activity of Th1 in patients with advanced lung cancer was lower than that in normal persons in peripheral blood. For non-outstanding curative effect or progressive state of illness, the activity of Th1 in patients of above 1 year survival time decreased in post-treatment than in pretreatment, the activity of Th2 increased in post-treatment. Conclusion： Activity of Helper T cells (Th1, Th2 ) could be an important marker to diagnose lung cancer and judge prognosis in patients with advanced lung cancer.
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