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Screening Tumor Antigens of Nasopharyngeal Carcinoma by Serological Proteomics Technologies
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Abstract:
Objective: To screen tumor antigens of nasopharyngeal carcinoma by serological proteomics technologies. Methods:The nasopharyngeal carcinoma cell line CNE-1 was used as a source of tumor cell proteins for Western blot analysis in which individual sera with special immunoreaction were selected and for immunoprecipitation analysis. Then, differential proteins are analyzed by mass spectrometry and bioinformatics methods.Results: Membrane-bound IgM was identified in the differential protein band. Conclusion: It may be a convenient, simple and sensitive way to screen tumor antigens by proteomics technologies. Membrane-bound IgM may probably be a novel antigen of nasopharyngeal carcinoma.
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