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Changes of Lymphocyte and Its Subsets After a Single Injection of Cyclophosphamide to Balb/c Mouse
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Abstract:
Objective : To explore the possible mechanism that single administration of low dose cyclophosphamide (CTX) has the ability to potentiate immunity in antitumor immunotherapy. Methods: Lymphocytes in peripheral blood and spleen were numerated after 50 mg/kg CTX was administrated intraperitoneally to Balb/c mice, and lymphocyte subsets were analyzed by flow cytometry on day 5 of the administration. Results: On day 1 to 5 after CTX administration, lymphocytes decreased promptly both in peripheral blood and in spleen, accompanying with the decrease in ratio of non-T lymphocyte subsets and the increase in ratio of T lymphocyte subsets in peripheral blood, and the increase in ratio of CD8+ T lymphocytes was more marked than that in ratio of CD4+ T lymphocytes. Conclusions: These changes might be associated with the immune potentiation effect of CTX, and our observation afforded some information in further investigating the mechanism of immune potentiation effect of CTX.
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