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The Cytotoxic Effect of Peritoneal Elicited Macrophages Induced by HSPgp96 on Anti-Tumor in vitro
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Abstract:
Objective: To evaluate the cytotoxic effect of PEM induced by HSPgp96 on anti-tumor in vitro. Methods:PEM separated from mice induced by thioglycolate were divided into three groups randomly: Culture medium in control; LPS-induced group; HSPgp96-induced group. The production of NO, the cytotoxic effect to H22 cells and the morphologic change of PEM were investigated separately by enzyme method, MTT assay and scanning electron microscope. Results:In vitro, HSPgp96 can increased NO production from PEM of mice and significantly enhance the cytotoxic effect of PEM to H22 cells as well as LPS. Conclusion:HSPgp96 can effectively induce the cytotoxic effect of PEM on anti-tumor in which NO is one of the capital effective molecules in vitro.
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