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The Inhibitory Effect of Usnic Acid on Proliferation of the PC-3M Cells
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Abstract:
Objective:To extract Usnic acid from usnea longisima ach, and to evaluate the ability of Usnic acid to inhibit growth of human prostate cancer cells PC-3M in vitro. Methods:The cells were observed by microscope.The cytotoxicity to cancer cells was determined by MTT assay. DNA synthesis was tested by 3H-TdR in corporation assay in the experiments. Results: There were significant differences between PC-3M cells lest group and control group. The Usnic acid had streng thened cytotoxicity, and the rate of 3H-TdR incorporation was lower than that of the control in a dose-dependent manner (r=0.9799, r=-0.9525). Conclusion: The results suggested that the Usnic acid has inhibitory effects on growth of human PC-3M cells in vitro.
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