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hMLH1 protein expression in esophagus squamous cell carcinoma, esophagus atypical hyperplasia, and normal esophagus tissues
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Abstract:
To observe the expression of hMLH1 protein in esophagus squamous cell carcinoma, atypical hyperplasia tissue and normal esophagus tissue, so as to discuss the relationship between hMLH1 expression and esophagus carcinogenesis. Methods: The specimens of esophagus squamous cell carcinoma, atypical hyperplasia and normal esophagus tissue were obtained from 92 esophagus carcinoma patients. Immunohistochemistry (IHC) staining technique was used to detect expression of hMLH1 protein. The relationship between hMLH1 expression with clinical parameters, such as gender, age, cancer differentiation level, infiltration depth, tumor stage, lymphatic metastasis, was analyzed. Results: The positive rates of hMLH1 protein in esophagus squamous cell carcinoma, and atypical hyperplasia tissue and normal esophagus tissue were 36.96%，56.52%, and 84.78%,respectively,with the former 2 significantly lower than the latter (P<001). The average age of patients negative of hMLH1 protein in tumor tissues was older than that of patients positive of hMLH1 (P<0.05). There was significant correlation between the expression of hMLH1 with tumor staging and lymphatic metastasis (P<0.05). Conclusion: Deletion of hMLH1 may participate in the carcinogenesis of esophageal squamous cell carcinoma at an early stage.hMLH1 gene may delay and suppress the development and progression of esophageal squamous cell carcinoma.
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