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Developing aptamers into tumor diagnostics and therapeutics
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Abstract:
Aptamers are small singlestranded nucleic acid molecules that bind a target protein with high affinity and specificity. Due to their stability, low toxicity and immunogenicity, as well as improved safety, aptamers are attractive alternatives to antibody and are therefore suitable for in vivo applications. Aptamers are typically isolated, through a process termed SELEX (systematic evolution of ligands by exponential enrichment), from combinatorial libraries with desired proteins. In the present review, the recent nonconventional aptamer selection process will be discussed together with an overview on the aptamer application in cancer diagnosis and therapy.
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