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Recent progress in metastasis mechanism of malignant tumors and their treatment strategies
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Abstract:
Although great achievement has been made on the diagnosis and treatment of malignant tumors, metastasis of tumor remains to be the major reason for treatment failure and death of their victims. The development of systematic biology and functional genomics give us a deeper understanding of the nature of metastasis at the molecular level. Based on the consensus reached on the metastasis mechanisms of cancer, including the genetic heterogeneity of cancer, premetastatic niche, epithelialmesenchymal transition, anoikis resistance, angiogenesis and lymphangiogenesis, etc, the targeted therapy at molecular level should be emphasized, the treatment should target the tumor stem cells, and RNAi technique and other techniques should be used in clinical antimetastatic therapy.
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Project Supported:
Surpported by the Science and Technology Foundation of Public Health of China (No.2006BAI02A00)
Clc Number:
