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Expression of epidermal growth factor receptor mRNA and vascular endothelial growth factor mRNA in ovarian carcinoma and its significance
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Abstract:
Abstract Objective: To explore the expression of the epidermal growth factor receptor (EGFR) mRNA and vascular endothelial growth factor (VEGF) mRNA in ovarian carcinoma and its significance. Methods: Reverse transcription polymerase chain reaction (RTPCR) was employed to determine the expression of EGFR mRNA and VEGF mRNA in 58 specimens, including 12 normal, 11 benign and 35 malignant ovarian carcinomas, which were obtained during operation from patients treated in the Affiliated Hospital of Qingdao University Medical College. The relationship between EGFR and VEGF mRNA expression and the clinicopathological features was analyzed. Results: The positive rates of EGFR and VEGF mRNA were significantly higher in the malignant ovarian specimens than in the normal and benign ones （P＜0.05). EGFR mRNA expression was correlated with the clinical stages of ovarian carcinomas, with the expression at stage ⅢⅣ significantly higher than that of stageⅠⅡ（P<0.05）. The expression of VEGF mRNA was correlated with the clinical stages and lymph node metastasis of ovarian carcinomas. VEGF mRNA expression in carcinomas of stage ⅢⅣ or those with lymph node metastasis was significantly higher than that at stageⅠⅡ and those without lymph node metastasis（all P<005）. Besides, the expression of EGFR mRNA was correlated with the expression of VEGF mRNA（r=0.438，P<0.05）.Conclusion: The expression of EGFR and VEGF is positively correlated with the carcinogenesis and metastasis of ovarian carcinoma, and there might be a synergistic effect between the 2.
Keywords:
epidermal growth factor receptor (EGFR ) ; vascular endothelial growth factor (VEGF) ; ovarian neoplasms ; expression ; pathologic characteristic
Project Supported:
Supported by the Science and Technology Foundation of Qingdao (No.KGD10)
