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Clinical Research
Combined examination of serum crosslinked Ntelopeptides of type Ⅰ collagen and bone sialoprotein in detection of bone metastasis of breast cancer and lung cancer
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Abstract:
Abstract Objective: To study the clinical significance of examining serum pyridinoline crosslinked Ntelopeptides of type I collagen (NTx) and serum bone sialoprotein (BSP) in diagnosing bone metastasis of lung cancer and breast cancer. Methods：A total of 105 patients treated in the Oncology Department of Changhai Hospital were included in this study. Patients were divided into 2 groups: bone metastasis (n=50) and nonbone metastasis groups (n=55). The levels of serum NTx and serum BSP were measured by ELISA. Results: The levels of serum NTx and serum BSP in patients with bone metastasis were significantly higher than in those without bone metastasis (P<0.01). The sensitivity and specificity of serum NTx in the diagnosis of bone metastasis were 90.0% and 67.3%, respectively; the sensitivity and specificity of serum BSP were 84.0% and 70.9%, respectively. Thirtytwo patients with bone metastases had skeletal related events (SRE) and they also had significantly higher levels of serum NTx (P<0.05). During the followup, 21 patients were diagnosed with newonset of bone metastasis. COX anlysis showed that the relative risk ratio for bone metastasis of higher serum NTx level was 1.127. Further analysis showed that serum BSP was the only risk factor for patients with breast cancer to develop bone metastasis (P<0.01), with the relative risk ratio being 1.058. During the followup 33 patients died. The cumulative survival rate of patients with higher serum BSP was lower than that with normal serum BSP level. Conclusion: The serum NTx and BSP were important biomarkers for diagnosis of bone metastasis. The two markers can be regarded as risk factors for bone metastasis. BSP might be an independent factor for predicting the prognosis of lung and breast cancer.
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Supported by the Shanghai Science and Technology Committee Foundation (No.060219505)
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