Mobile website
Clinical Research
Expression of activated mTOR in gallbladder carcinoma tissue and its clinical significance
- Article
- Figures
- Metrics
- Preview PDF
- Reference
- Related
- Cited by
- Materials
Abstract:
Objective:To investigate the expression of phosphorylatemammalian target of rapamycin, pmTOR, in human gallbladder carcinoma and its clinical significance. Methods: Six chronic cholecystitis tissues, 7 adjacent gallbladder carcinoma tissues and 59 gallbladder carcinoma tissues, obtained from Department of General Surgery, People′s Hospital of Pudong New Area and Department of Oncology of Changzheng Hospital from 2004 to 2007, were evaluated by immunohistochemistry and tissue microarray for pmTOR expression. The correlations among pmTOR expression with gallbladder carcinoma invasion, differentiation and Nevin stage were analyzed. Results: The positive rates of pmTOR in chronic cholevstitis, adjacentneoplatic gallbladder carcinoma and gallbladder carcinoma tissue were 0, 0 and 47.5%, respectively (P<0.01). The positive rates of pmTOR in with well, moderately and poorlydifferentiated gallbladder carcinoma tissues were 21.4%, 48.1% and 66.7%, respectively; there were a significant differences among the three groups（P<0.01）. The positive rates in gallbladder carcinoma tissue with mucosa and muscle invasion, serous membrane invasion and peripheral tissue invasion were 30%, 35.7% and 71.40%, respectively（P<0.01）. The positive rates in Ⅰ/Ⅱ, Ⅲ/Ⅳ and Ⅴ stage gallbladder carcinoma tissues were 11.1%, 46.4% and 66.7%, respectively, showing a significant increasing trend（P<0.01）. Conclusion:The expression of pmTOR is closely related with low differentiation, invasion and clinical stage (Nevin stage) of gallbladder carcinoma and may participate in the development and progression of gallbladder carcinoma.
Keywords:
Project Supported:
Clc Number:
