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Expression of LMP1, NET1, and VEGF in nonkeratin nasopharyngeal carcinoma and its clinical significance
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Abstract:
Objective:To investigate the expression of latent membrane protein1 (LMP1) , NET1, and vascular endothelial growth factor (VEGF) in nonkeratin nasopharyngeal carcinoma (NKNPC) and its clinical significance. Methods:Sixty biopsy specimens from pathologicallyconfirmed NKNPC patients, who were treated in the Affilitated Hospital of Nantong University from May 1999 to May 2003, were included in the present study. Using immunohistochemical techniques (Envison twostep), we examined the expression of LMP1, NET1 and VEGF protein in the specimens. The relationship between their expression and clnicopathological parameters and the prognosis was anayzed. Ten specimens of chronic nasopharyngitis served as control. Results:(1) The positive rates of LMP1, NET1 and VEGF in NKNPC were significantly higher than those in the chronic nasopharyngitis (P<0．05). (2) The LMP1 expression in NKNPC specimens were positively correlated with distant metastasis of NKNPC (P<0．05)，and not correlated with the sex，age，T stages and N stages (P＞0．05)． (3) NET1 and VEGF expression in NKNPC specimens were positively correlated with lymph node metastasis and distant metastasis (P<0.05), and not correlated with the sex，age，and T stages． (4) The expression of LMP1, NET1, and VEGF was correlated with each other (P<0.05)．(5) Kaplan-Meier survival curve analysis showed that the expression of LMP1, VEGF was significantly correlated with the prognosis of NKNPC patients (P<005)．Conclusion: Combined examination of LMP1, NET1, and VEGF can help to predict NPC metastasis and prognosis. LMP1 and VEGF might be used as an indicator for prognosis of NKNPC．
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