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Clinical Research
Expression of Clusterin in colorectal cancer tissues and its relationship with clinicopathological properties
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Abstract:
Objective: To observe the expression of Clusterin in colorectal cancer tissues and study its relationship with the development and progression of colorectal cancer. Methods： Fiftyeight colorectal cancer tissues samples (32 rectal cancer tissues, 26 colon carcinoma tissues) of patients with completed clinic data were obtained after surgery from the Affiliated Hospital of Guangdong Medical College. Immunohistochemical staining (SP method) was used to detect the expression of Clusterin in colorectal cancer tissue, adjacent normal tissue of colorectal cancer and normal tissue. Flow cytometry was used to examine the apoptosis of colorectal cancer cells. Results： The expression of Clusterin in colorectal cancer tissues was significantly higher than those in the adjacent tissues of colorectal cancer and normal colorectal tissue（P＜005); besides, the expression of Clusterin in the colorectal cancer tissue was correlated with the differentiation, Dukes stages and lymphatic metastasis of colorectal cancer. Apoptosis of colorectal cancer cells was found correlated with the clinical stage and lymphatic metastasis; Clusterin expression in colorectal cancer tissue was negatively correlated with apoptosis of colorectal cancer cells (r=-0.381, P<0.05). Conclusion： Clusterin may play important roles in the development and progression of colorectal cancer by inhibiting apoptosis of tumor cells, which may pave a way for immunotherapy of colorectal cancer.
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