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Expression of adrenomedullin in breast cancer tissues and its relationship with differentiation and metastasis of breast cancer
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Abstract:
Objective: To investigate the expression of adrenomedullin (ADM) in breast cancer tissues and its relationship with differentialtion and metastasis of breast cancer. Methods: RTPCR was used to examine ADM mRNA expression in 32 breast cancer tissues (the patients were treated in the Fourth Affiliated Hospital of Hebei Medical University from March 2005 to April 2005) and the corresponding adjacent tissues (5 cm away from tumors), as well as in MCF7 cell line. Expressions of ER， PR and CerbB2 in breast cancer were examined by immunohistochemical staining. Results: Human breast cancer cell line MCF7 was positive of ADM. ADM mRNA expression was detected in 75% (24/32) breast cancer samples, which was significantly higher than that in the corresponding adjacent tissues (0%, 0/32, P<0.01). We found that ADM expression was correlated with the differentialtion degree and lymph node metastasis of breast cancer (P<0.01 and P<0.05, respectively), and was not correlated with the expression of EP, PR or CerbB2, the tumor size, TNM staging, or the pathological types. Conclusion: The expression of ADM is increased in breast cancer tissues, which is correlated with the poor differentiation and lymph node metastasis of the breast cancer.
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Project Supported:
Supported by the Development Program of Science and Technology Commission of Hebei Province (No.0527611D57)；the Strong Characteristic Subject of Colleges and Universities of Hebei Province (No. 200552)
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