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Expression of Survivin gene in gastric carcinoma and its relationship with Bcl-2 and Bax expression
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Abstract:
Objective:To investigate the expression of Survivin gene in gastric carcinoma and its relationship with Bcl2 and Bax expression, as well as their roles in the development and progression of gastric carcinoma. Methods: Fiftyfour paraffin blocks were obtained from patients with gastric carcinoma receiving surgery. The diagnosis of these patients was confirmed by pathology in our Hospital from 20052007; no patients received chemoradiation therapy before surgery. Fifteen benign gastricmucosa tissues were used as control. SP immunohistochemistry was used to detect Survivin, Bcl2 and Bax expression in gastric carcinoma tissues, and Survivin in 15 benign gastric mucosa tissues. Results: Survivin was positive in 39 of the 54 tissues, with a positive rate of 72.2%. Survivin expression was not detected in the 15 benign gastricmucosa tissues. Expression of Survivin in gastric carcinoma tissues was correlated with the invasion, lymph nodes metastasis and TNM stage of gastric carcinoma, but not with patients′ sex and age, tumor size, remote metastasis or cell histological stage. Positive rate of Survivin expression in Bcl2 positive gastric carcinoma tissues was 81.8% (27/33) and the rate was 63.6% (14/22) in Bcl2 negative gastric carcinoma tissues. Survivin expression in gastric carcinoma tissues was correlated with the expression of Bcl2 but not with Bax (P<0.05). Conclusion: Expression of Survivin in gastric carcinoma tissues is correlated with the invasion, lymph node metastasis and TNM stage of gastric carcinoma. Survivin expression in gastric carcinoma tissues is positively correlated with the expression of Bcl2 but not with Bax (P<005).
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