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Characteristics of dendritic cells derived from different monocyte subtypes and their functions in tumor immunotherapy
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Abstract:
Dendritic cells (DCs) have different subtypes with distinct phenotypes and biological functions. Meloyiod dendritic cell subtype is one of the most important DCs subtypes. Recent studies have revealed that human monocytes were composed of CD14++CD16- and CD14+CD16+ subtypes, and mouse monocytes consisted of CD115+Ly6Chigh and CD115+Ly6Clow/ subtypes. Different monocyte subsets differentiate into different dendritic cells subsets with distinct phenotypes and induce different types of immune responses in vivo or in vitro. Under steady state, mouse CD115+Ly6Clow monocyte subtype is an important precursor of dendritic cells in peripheral organs and tissues, but in inflammatory response, CD115+Ly6Chigh monocyte subtype is the main precursor of dendritic cells in peripheral lymphoid organs. CD115+Ly6Chigh monocyte derived dendritic cells can directly present antigens that acquired in peripheral tissues after differentiating into dendritic cells, and transfer their MHCⅠ/peptide complex to residential dendritic cells as well. The cooperation and interaction of dendritic cells from different sources enable the immune system to respond to different stimuli properly.
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Project Supported:
Supported by the National Natural Science Foundation of China (No.30872301)
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