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Clinical Research
Expression of negative costimulatory molecules B7-H1 and B7-H3 in breast cancer and their clinical significance
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Abstract:
Objective:To investigate the expression of negative costimulatory molecules B7H1 and B7H3 in breast cancer and its relationship with patient's clinical parameters, prognosis and infiltration of CD3+ T lymphocytes. Methods: Fortynine breast cancer patients, who were diagnosed as having infiltrating ductal breast cancer histopathological were selected from Third Affiliated Hospital of Suzhou University from March 2003 to January 2004. B7H1 and B7H3 expression and CD3+ T lymphocytes infiltration in breast cancer tissues were detected by immunohistochemistry. Results: (1) B7H1 positive expression rate was 53.06%(26/49) in breast cancer tissues; the expression was positively correlated with the tumor size (P<0.05) and Her2/neu expression (P<0.05), and negatively with the intensity of CD3+ T infiltration (P<0.05). (2) B7H3 positive expression rate was 59.18%（29/49）in breast cancer tissues; the expression was positively correlated with patient′s pathological stage (P<0.05) and negatively with postoperative prognosis (P<0.05). (3) B7H1 expression in breast cancers was positively correlated with B7H3 expression (r=0.3316, P<0.05). Conclusion:Expression of negative costimulatory molecules B7H1 and B7H3 in breast caner is significantly correlated with the clinicopathological parameters and postoperative prognosis of patients. B7H1 and B7H3 might have a potential role in clinical diagnosis and prognostic evaluation of breast cancers.
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Supported by the Innovative Research Project for Postgraduates in Colleges of Jiangsu Province(No.ZY320710)
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