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Expression of Ets-1 and VEGF in breast invasive ductal carcinoma and its clinical significance
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Abstract:
Objective:To study the expression of Ets1 and VEGF in breast invasive ductal carcinoma (IDC) tissues, and to analyze its correlation with clinicopathologic characteristics of IDC. Methods: Forty breast IDC tissues and their adjacent normal tissue samples were obtained from clinical diagnosed breast IDC patients after surgery. Expression of Ets1 and VEGF protein and mRNA was examined by immunohistochemistry and RTPCR. Results:（1）Expression of Ets1 and VEGF protein in breast IDC tissues was significantly higher than that in adjacent normal tissues (P<0.01). Expression of Ets1 protein in breast IDC tissues was significantly higher than that of VEGF and their expressions were positively correlated (r=0.8827, P<0.05). Expression of Ets1 and VEGF protein was correlated with the clinical stages of breast IDC and lymph node metastasis (P<0.05).（2）Expression of Ets1 and VEGF mRNA in breast IDC tissues was significantly higher than that in adjacent normal tissues (P<0.01). Expression of Ets1 mRNA in breast IDC tissues was significantly higher than the expression of VEGF and they were positively correlated (r=0.984, P<0.01). Expression of Ets1 and VEGF mRNA was correlated with the clinical stage and lymph node metastasis of breast IDC (P<005), but not with patient′s ages and tumor volumes. Conclusion: Ets1 and VEGF are highly expressed in breast IDC tissues at both mRNA and protein, and they are positively correlated with each other. Their expression is associated with the clinical stages and lymph node metastasis of breast IDC.
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Supported by the Scientific Research and Technological Development Program of Guilin, Guangxi Province (No.20070514)
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