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Clinical Research
Determination of serum HER2 in breast cancer patients and its clinical significance
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Abstract:
Objective: To study HER2 levels in the serum and breast cancer tissues and their correlation with clinical parameters, so as to explore drugs selection and prognosis prediction of breast cancer. Methods: Sixtyseven pathologicallyconfirmed breast cancer patients, 20 patients with breast benign tumor, and 20 healthy women, who were treated in Fujian tumor hospital from Jan. 2008 to Oct. 2008 were included in this study. Expression of HER2 in breast cancer tissues was examined by immunohistochemistry, and serum HER2 level in breast cancer patients was examined by ELISA. Results: Serum level and positive rate of serum HER2 in breast cancer patients were significantly higher than those in healthy women and breast benign tumor patients (P<0.05). Serum HER level and positive rate of serum HER2 in histological HER2 positive breast cancer patients were significantly higher than those in histological HER2 negative patients (P<0.05), with the positive rate of serum HER positively correlated with histological HER2 status. The result of serological method was consisted well with the histological method in the determination of HER2 status in breast cancer patients. Serum HER2 level in some histological HER2 negative primary breast cancer patients was increased after recurrence and metastasis, and positive rate of serum HER2 in Ⅳ metastatic breast cancer patients was significantly higher than that in ⅠⅢ metastatic breast cancer patients (P<0.05). Conclusions: Serum HER2 level is elevated in breast cancer patients, and positive rate of serum HER2 is correlated with histological HER2 status and clinical stages of cancer. Determination of serum HER2 may be useful in diagnosis, HER2 status evaluation and prognosis prediction of breast cancer patients.
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Project Supported:
Supported by the Medical Innovation Project of Fujian Province （No.2007CXB1)
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