Mobile website
Clinical Research
Glucoseregulated protein 78 expression in human esophageal squamous cell carcinoma and its correlation with tumor biological behavior
- Article
- Figures
- Metrics
- Preview PDF
- Reference
- Related
- Cited by
- Materials
Abstract:
Objective:To investigate the expression of glucoseregulated protein 78 in human esophageal squamous cell carcinoma and normal esophageal tissues, and to evaluate its correlation with clinical pathological characteristics of esophageal squamous cell carcinoma. Methods: Fiftynine specimens of human esophageal squamous cell carcinoma and twenty adjacent normal specimens were collected from the patients who received operation for esophageal squamous cell carcinomas in our Hospital between Oct. 2007 and Nov. 2008. GRP78 mRNA and GRP78 protein expressions were examined by RTPCR assay and Western blotting, respectively. The relationship between GRP78 expression with clinical parameters of patients, such as gender, length of tumor, tumor infiltration depth, tumor differentiation grade stage, and lymphatic metastasis, was analyzed. Results: GRP78 mRNA and GRP78 protein expression levels in human esophageal squamous cell carcinoma were significantly higher than those in the normal esophageal tissues (all P<0.01). GRP78 expression in esophageal squamous cell carcinoma tissues was correlated with the infiltration depth, grade of differentiation(P<0.05 or P<0.01), stage of tumors (P<0.01), and lymphatic metastasis (all P<0.01), but not with gender or the length of tumor (P>0.05). Conclusion: GRP78 participates in the development, progress of esophageal squamous cell carcinomas, and its expression is positively associated with the malignancy of carcinoma. GRP78 may be taken as a potential biomarker in evaluating the malignancy of esophageal squamous cell carcinoma.
Keywords:
Project Supported:
Clc Number:
