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Expression of osteopontin in spinal plasma cell myeloma patients and its clinical significance
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Abstract:
Objective: To investigate the expression of osteopontin (OPN) in spinal plasma cell myeloma (PCM) and its relationship with the clinicopathological characteristics and prognoses of PCM patients. Methods: Fortyone PCM and 14 spinal simple bone cysts samples were obtained from Affiliated Changzheng Hospital of Second Military University (19982006) after surgery. The expression of OPN was determined by streptavidinperosidase (SP) immunohistochemical staining. Results: (1) The positive expression rate of OPN in spinal PCM tissues was 82.93% (34/41), and it was absent in spinal simple bone cyst tissues(P<0.01). (2) The expression of OPN in spinal PCM tissues was correlated with clinical and Mcomponent classifications of PCM (P<0.05)，but was not correlated with the type of light chain, pathological stage, age or gender of patients (P>0.05). (3) The overall survival rate of OPN positive PCM patients was higher than that of OPN negative patients (P<0.01). Conclusion: OPN negative PCM patients are liable to have a poor prognosis. The clinical and Mcomponent classifications combined with detection of OPN expression in PCM patients maybe used for predication of prognoses of PCM patients.
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Supported by the Scientific Research Starting Foundation for Young Scholars in Affiliated Changzheng Hospital of Second Military Medical University (No. 200915)
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