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Expression of IL-13Rα2 and PCNA in malignant glioma and its relationship with pathological characteristics and prognosis
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Abstract:
Objective:To examine the expression of IL13Rα2 and proliferating cell nuclear antigen (PCNA) in malignant glioma, and to investigate its relationship with clinical pathological characteristics and prognosis. Methods:Fortythree surgical samples of malignant glioma were obtained from First Affiliated Hospital of Wenzhou Medical College during 20022006. Expression of IL13Rα2 and PCNA proteins was examined by immunohistochemistry staining, and the integrated optical density (IOD) was analyzed by image analysis system. The correlation between the expression of IL13Rα2 with that of PCNA, and their relationship with clinical characteristics and prognosis of glioma were studied.Results: (1) The positive rates of IL13Rα2 and PCNA in malignant glioma tissues were 93% (40/43) and 84% (36/43), respectively. (2) No relationship of IL13Rα2 and PCNA expression with the location and tumor size of glioma was found (P>0.05). The expression of IL13Rα2 and PCNA in glioma was significantly different between Ⅲ grade and Ⅳ grade glioma tissues (P=0.031, P=0.002). Patients who survived less than 6 months had a significantly higher expression of IL13Rα2 than those who survived more than 6 months (P=0.028). (3) The expression of IL13Rα2 was positively correlated with that of PCNA (r=0.653, P=0.000). Conclusion: IL13Rα2 and PCNA are overexpressed in malignant glioma tissues, and IL13Rα2 expression is correlated with differentiation grade and prognosis of glioma. IL13Rα2 has potential roles in clinical diagnosis and prognositic evaluation of malignant glioma.
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