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Clinical Research
Expression of negative costimulatroy molecule B7-H4 in non-small cell lung cancer tissues and its clinical significance
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Abstract:
Objective: To study the expression of negative costimulatroy molecule B7H4 in nonsmall cell lung cancer (NSCLC) tissues and its relationship with the clinical features of NSCLC. :Methods: :Fiftytwo NSCLC specimens from patients who were pathologically diagnosed in our hospital during January 2008 to April 2009 were included in the present study. B7H4 expression and infiltration of CD3+T cells in NSCLC tissues were detected by immunohistochemistry. The correlation between B7H4 expression, CD3+T infiltration, and the clinical features of NSCLC was studied. :Results:: The positive rate of B7H4 in 52 NSCLC tissues was 48.08% (25/52), and B7H4 expression in normal lung tissues was negative or low (P<0.05). B7H4 expression was positively correlated with the clinical tumor stages and lymph node metastasis of NSCLC (P<0.05), and negatively correlated with tumor infiltration of CD3+T cells (P<0.05), but had no relationship with clinicopathologic parameters of NSCLC (P>0.05). :Conclusion: :Negative costimulatroy molecule B7H4 may play important roles in the development of NSCLC. Positive expression of B7H4 is correlated with the clinical tumor stages and lymph node metastasis of NSCLC, which provides a foundation for diagnosis and therapy of NSCLC.
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