miRNA mediated biological behavior changes of tumors

doi:10.3872/j.issn.1007-385X.2010.1.022

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Archive > Volume 17 Issue 1 > 2010,17(1):109-114. DOI:10.3872/j.issn.1007-385X.2010.1.022 Prev Next

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miRNA mediated biological behavior changes of tumors

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Abstract:

miRNA is a kind of endogenous noncoding short RNA. Mature miRNA was formed through the process of shearing and transporting after genetic transcription. miRNA exhibits many important biological functions through regulating expression and translation of target mRNAs. Different miRNAs may act as oncogenes or antioncogenes, and have tissue specificity. The progress of the tumorigenesis is usually accompanied by expressionprofile changes of miRNAs. MiRNA regulates many tumor biological behaviors such as differentiation, proliferation, apoptosis, invasion, metastasis, and drug resistance of tumors. Furthermore, some miRNAs have clinical significance in predicting prognosis of tumor patients.

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Project supported by the Major Program of Medical Science Research of Hebei Province（No.20090169）

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