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Biotherapy of Ewing’s sarcoma: Current status of basic research
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Abstract:
Biotherapy is especially beneficial for Ewing’s sarcoma with bad prognosis. The therapy includes gene therapy, immunotherapy, antiangiogenesis therapy, etc.. Gene therapy mainly refers to the application of antisense nucleic acid technique; immunotherapy refers to antibody therapy, T cell therapy, dendritic cell therapy, and tumor vaccine,etc.; and antiangiogenesis therapy refers to inhibition of tumor angiogenesis, thus suppressing tumor growth and metastasis. With the deeper understanding of Ewing’s sarcoma, changes in the telomere length, microsomal glutathione Stransferase 1 (MGST1) expression, the expression of tumor metastasis and multidrug resistance genes, and papillomavirus binding factor might serve as novel predictors for the prognosis of Ewing’s sarcoma.
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