Roles of tumor suppressor gene P27in acute leukemia

doi:10.3872/j.issn.1007-385X.2010.3.022

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Archive > Volume 17 Issue 3 > 2010,17(3):354-358. DOI:10.3872/j.issn.1007-385X.2010.3.022 Prev Next

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Roles of tumor suppressor gene P27in acute leukemia

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Abstract:

Biotherapy is especially beneficial for Ewing’s sarcoma with bad prognosis. The therapy includes gene therapy, immunotherapy, antiangiogenesis therapy, etc.. Gene therapy mainly refers to the application of antisense nucleic acid technique; immunotherapy refers to antibody therapy, T cell therapy, dendritic cell therapy, and tumor vaccine,etc.; and antiangiogenesis therapy refers to inhibition of tumor angiogenesis, thus suppressing tumor growth and metastasis. With the deeper understanding of Ewing’s sarcoma, changes in the telomere length, microsomal glutathione Stransferase 1 (MGST1) expression, the expression of tumor metastasis and multidrug resistance genes, and papillomavirus binding factor might serve as novel predictors for the prognosis of Ewing’s sarcoma.

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Project supported by the Innovation Foundation for Graduate of Kunming Medical College (No. KM2008L17)

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