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Preparation of ironcarbon nanoparticles and its application in tumor therapy: Recent progress
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Abstract:
Ironcarbon nanoparticles include ironcarbon nanoparticles, carboncoated iron nanoparticles, etc., which can be prepared by mechanical trituration, carbon arc, gas phase deposition, pyrolysis and explosion methods. Ironcarbon nanoparticles have good adsorptive and magnetic effects, and they are perfect carriers for chemotherapeutic drugs, such as adriamycin, mitomycin and carboplatin, etc. Ironcarbon nanoparticle complex has highdrug loading and stable release abilities, thus can maintain sufficient drug concentration for inhibition of tumor cell proliferation. In addition, they can greatly aggregate in target organs, reducing the adverse and toxic effects to nontarget organs. Moreover, ironcarbon nanoparticles have magnetic induction ability and can kill tumor cells by thermogenic effects, whose intensity is correlated to the amount, concentration and action time of induced electric field. Great progress has been made in the research of ironcarbon nanoparticles as magnetic carriers for chemotherapeutic drugs in vitroand in vivo, and it is believed to have great values in clinical tumor therapy in future.
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Project Supported:
Project supported by the Innovation Foundation for Graduate of Kunming Medical College (No. KM2008L17)
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