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Clinical Research
Investigation of immune microenvironment of primary hepatocellular carcinoma
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Abstract:
Objective: To investigate the infiltration and distribution of immunocytes in primary hepatocellular carcinoma (HCC) tissues. Methods: Thirty HCC tissues were obtained from Tumor Hospital of Fujian Province. The expressions of CD3+, CD4+, CD8+, FoxP3+, CD20+, CD56+, and CD68+ cells in liver tumor tissues, liver peri-tumor tissues and non-tumor liver tissues were detected by immunohistochemistry S-P assay. Results: Immunohistochemistry results showed that the numbers of CD3+, CD4+, FoxP3+ cells were highest in liver peri-tumor tissues, less in liver tumor tissues, and least in the corresponding non-tumor liver tissues (P<0.05); the numbers of CD8+, CD56+, CD68+ cells were highest in the liver peri-tumor tissues, less in non-tumor liver tissues, and least in liver tumor tissues (P<0.05); and the CD20+ cell numbers had no significant difference between liver tumor tissues, liver peri-tumor tissues, and non-tumor liver tissues (P>005). CD3+, CD4+, CD8+, CD56+, and CD68+ cells were mainly distributed in the mesenchyma of the liver tumor tissue, and FoxP3+ cells were scattered among the whole tumor tissue. Conclusion: Cytotoxic immunocyte is decreased and the inhibitory immunocyte is increased in the microenvironment of hepatocellular carcinoma, which results in an immunosuppression status in tumor tissues.
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Project supported by the Key Foundation of Science and Technology Bureau of Fujian Province（No.2008I0012）
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