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eIF4E and tumor
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Abstract:
Eukaryotic translation initiation factor 4E (eIF4E) is one of the factors closely associated with the malignant tumors. It can specifically bind to the cap structure of mRNA 5′end and plays an important role in regulating the initial stage of protein synthesis. The activity of eIF4E is regulated by the phosphorylation, the phosphorylation of translation inhibitory protein and nuclear factors. EIF4E is highly expressed in many human malignancies and is related to development, invasion and metastasis of tumors. Previous researches about eIF4E have indicated it as a cancer therapeutic target; these researches included those using small interfering RNAs to suppress the expression of eIF4E, drugs to block AKT/mTOR or Raf/MEK/ERK signaling pathways, small molecule inhibitor of 4EG1 to inhibit cap-dependent translation; they inhibit tumor growth through decreasing the levels of eIF4E phosphorylation. EIF4E is expected to become a new target for malignant tumor biotherapy.
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Project Supported:
Project supported by the Major Foundation of Science and Technology Commission of Shanghai Municipality (No.05NM05026)
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