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Tumor-associated neutrophils in tumor development and progression
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Abstract:
In addition to the cancer cells, there are many other cells in the tumor microenvironment, such as the stromal cells, endothelial cells, CD4+ and CD8+ lymphocytes, NK cells, macrophages and neutrophils, etc. Recent studies have found that tumor-associated neutrophils (TANs) play important roles in the development and progression of tumors. TANs can promote tumor development and metastasis through various mechanisms, such as TANs promoting tumor proliferation and metastasis by secreting elastase, promoting tumor angiogenesis by secreting matrix metalloproteinase, and highly activated TANs exerting anti-tumor activity by killing tumor cells. Further study on TANs casts new lights on immunotherapy of tumors; and using TANs and molecules secreted by TANs as targets may become an important strategy for inhibiting the development and progression of tumors.
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Project Supported:
Project supported by the National Natural Science Foundation of China (No. 30872377)
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