Mobile website
Clinical Research
Expressions of Syk, c-erbB-2 and EGFR in gastric cardiac adenocarcinoma and relevant clinical significance
- Article
- Figures
- Metrics
- Preview PDF
- Reference
- Related
- Cited by
- Materials
Abstract:
Objective: To investigate the expressions of Syk (spleen tyrosine kinase), c-erbB-2 and epidermal growth factor receptor (EGFR) in gastric cardiac adenocarcinoma (GCA) and corresponding adjacent normal tissues, and to discuss their relationship with development and progression of GCA. Methods: Ninety-one GCA samples were obtained from the Fourth Hospital of Hebei Medical University (from Oct. 2006 to Dec. 2007). The expressions of Syk, c-erbB-2 and EGFR in GCA and corresponding adjacent normal tissues were determined by immunohistochemistry, and their correlations were analyzed. Results: The positive expression rate of Syk in GCA tissues was 24.18%, which was significantly lower than that in the adjacent normal tissues (60.44%, P<0.01). And the positive expression rates of c-erbB-2 and EGFR in GCA tissues were 56.04% and 58.24%, respectively, which were also higher than those in the adjacent normal tissues (P<0.01). The expressions of Syk and c-erbB-2 were correlated with pathology grade, lymphatic metastasis and TNM stage of GCA, and EGFR expression was only correlated with lymphatic metastasis. The expression of Syk was correlated with those of c-erbB-2 and EGFR (P<0.05), but Syk expression had no correlation with EGFR expression (P>0.05). Conclusion: Syk, c-erbB-2 and EGFR are abnormally expressed in GCA, which may contribute to pathogenesis of GCA. The combined detection of Syk, c-erbB-2 and EGFR may have potential significance in prognosis prediction of GCA.
Keywords:
Project Supported:
Project supported by the Science and Technology Research and Development Program of Hebei Province (No.072761223)
Clc Number:
