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Clinical implication of cancer stem cells
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Abstract:
Cancer stem cells (CSCs) are special stem cells recently found in many tumor tissues. CSCs are capable of self-renewal and differentiation. They can gradually differentiate into tumor cells and form new tumors; they can also be resistant to chemotherapy and radiotherapy, which may partly explain the recurrence and metastasis of tumors. CSCs can be used for diagnosis and treatment of tumors, since some tumors can be early diagnosed by detecting certain CSC markers. Some novel therapy strategies target signal transduction pathways, surface molecular markers and tumor microenvironments of CSCs, as well as induce differentiation of CSCs. Further insights into drug-resistance of CSCs and the identification of more CSCs markers may offer new therapeutic strategies for tumors.
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Project Supported:
Project supported by the National High Technology Research and Development Program of China (No.2006AA02A205)
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